The effectiveness of troclosan coated polglactin 910 in reducing surgical site infection in clean wounds a randomised trial

ABSTRACT

Background: Surgical site infection(SSI) is a major cause of morbidity, mortality and financial burden in healthcare. Worldwide it accounts for as much as $10 billion annually in direct and indirect medical cost. Many strategies has been developed to try and reduce SSI.

Objective: To determine the effectiveness of triclosancoatedpolyglactin 910 sutures in reduction of superficial surgical site infection in clean wounds.

Study design: This was a non-blinded randomised controlled trial.

Setting:  Kenyatta national hospital, the minor theatre in clinic 24.

Sample size: A total of 157patients underwent excision of breast lump.

Methods: Patients for minor clean wound surgery were randomly divided into two groups. In one group the wounds were closed subcutaneously with triclosan coated polyglactin 910 suture, while in the second group plain polyglactin 910 suture was be used. The wounds were examined on the 3rd, 7th and 30th day post operatively, for signs of superficial SSI. There was no use antibiotics perioperatively. However for patients who develop SSI, treatment was offered.

Results: The prevalence rate of SSI in the study group was 5% (4 of 79patients) while in the control group it was 4% (3 of 78). The difference between the two groups was not statistically significant (P-value 0.507).

Conclusion: This study did not demonstrate a reduction of superficial surgical site when triclosan coated polyglactin 910suture was used in clean wounds. More studies are needed to look at its effects on other wounds. Currently the clinical role and indication for use of vicryl plus is yet to be fully defined.

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